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Image Search Results
Journal: Frontiers in Pharmacology
Article Title: Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice
doi: 10.3389/fphar.2024.1352842
Figure Lengend Snippet: Diagrams depicting the structures of ADAMTS13, MDTCS, and MDTCS-Fc. The MDTCS fragment is a truncated form of ADMTS13 and consists of the M, D, T1, C, and S domains essential to cleave vWF multimers. MDTCS-Fc consists of MDTCS, an IgG1 type hinge, and an IgG4 type Fc harboring YTE mutations to improve the FcRn binding affinity. M: metalloprotease domain, D: disintegrin-like domain, T1: the first thrombospondin type 1 repeat, C: Cys-rich domain, S: spacer domain, T2-8: the second to eighth TSP1 repeats, CUB: Complement c1r/c1s, sea Urchin epidermal growth factor, and bone morphogenetic protein, Fc: Fragment crystallizable.
Article Snippet: A
Techniques: Binding Assay